Clever girl Changed Idiot For Autoimmune Diseases
New York, the doctors and experts neurologist desperate to solve the mysterious illness suffered 19 years old girl from New York. The girl, known as an intelligent and achieving it was a sudden onset of brain deterioration, often hallucinating, laughing and crying for no reason and looking like an idiot.
Five neurologist, a pathologist and three psychiatrists admitted the difficulty to detect the disease that she had left the bench the college for a year. Peculiarity began in 2007 when the 16-year-old girl. In a dance show, he suddenly fell silent and did not respond to anything, such as frozen in place.
I wonder what happened, but since then he had a brain decline, become unresponsive, difficult to read and his face fell like an idiot. Sometimes his friends would catch the interest of toilet paper and crying constantly alone there. The girl was considered a mental disorder and began to be teased by his friends.
At the suggestion of the school psychologist, the girl finally taken to the doctor neurologist. But instead acquired a bright spot, the doctor actually suggested that the girl was taken to the shelter because the kids do all kinds of tests, type unknown what her illness. Even the doctors thought the girl was only pretending to be.
The mother is as confused as the doctor finally decided to try to treat at home with the hope the disease can be cured. But the more days, more and more bizarre behavior. "He started to laugh alone and hallucinating weird," his mother said as quoted by Forbes, Saturday (16/1/2010).
Some doctors and psychiatrists to diagnose the symptoms as the disease schizoprenia and gave antipsychotic drugs. But the drug also not immune to reduce the strangeness of the girl herself. There is also a suspected hit by epilepsy and other diseases. Psychiatrists and doctors became another argument about whether this includes mental illness or neurological disease.
Although MRI was performed tests and electroencephalogram (EEG), but all the results indicate that normal brain activity, there is no unusual findings in the brain. The case of this mysterious illness eventually attract the attention of Dr. Najjar Souhel from NYU's Langone Medical Center. "The first time I saw him, I am very sure he is not only psychiatric disease but also neurological disease," said Dr. Najjar.
"One reason is the dramatic decline of a smart girl and achievement becomes an idiot looking girl," he added. Najjar suspected, there is inflammation in the brain that are not detected by means of magnetic resonance imaging (MRI). Najjar also found several strange antibodies in his body.
"My estimate is that this girl had a rare autoimmune disease, in which the body's immune system actually attacks parts of the body healthy," said Najjar. Prediction and prediction Dr Najjar was indeed true. An antibody test performed, and the results showed that antibodies produced by the body of the girl known to attack the enzyme glutamic acid decarboxylase (GAD).
Enzyme GAD is an enzyme that controls production of a chemical called gamma-aminobutyric acid (GABA), which is a substance that allows the brain to communicate and think. When the body's immune system attacking the GAD enzyme production of GABA become restricted substances. This imbalance will cause psychiatric symptoms and unusual brain's cognitive abilities decline.
Brain biopsy was performed to complete and convincing diagnosis Dr. Najjar. And the results were surprising, to find the girl's brain nerve cells that have died of it comes from inflammation. "That means, antibodies had attacked his brain for years and accumulate until the brain is not strong anymore," said Najjar.
To suppress the inflammation that is not getting worse, Najjar injected corticosteroids on the girl's brain. Immunoglobulin substance was inserted through blood vessels to increase antbodi 'good' antibodies to fight 'evil'. Now, the girls began to show progress. "He talked more and a little delirious. The doctor also said he could continue his schooling," said the mother.
GAD autoimmunity including a mysterious disease that affects fewer people than the entire existing world population. Some children were known to have diabetes antibodies that are directly related to GAD in pancreatic cells. GAD cases experienced by girls.(as cited by Forbes magazine)
Five neurologist, a pathologist and three psychiatrists admitted the difficulty to detect the disease that she had left the bench the college for a year. Peculiarity began in 2007 when the 16-year-old girl. In a dance show, he suddenly fell silent and did not respond to anything, such as frozen in place.
I wonder what happened, but since then he had a brain decline, become unresponsive, difficult to read and his face fell like an idiot. Sometimes his friends would catch the interest of toilet paper and crying constantly alone there. The girl was considered a mental disorder and began to be teased by his friends.
At the suggestion of the school psychologist, the girl finally taken to the doctor neurologist. But instead acquired a bright spot, the doctor actually suggested that the girl was taken to the shelter because the kids do all kinds of tests, type unknown what her illness. Even the doctors thought the girl was only pretending to be.
The mother is as confused as the doctor finally decided to try to treat at home with the hope the disease can be cured. But the more days, more and more bizarre behavior. "He started to laugh alone and hallucinating weird," his mother said as quoted by Forbes, Saturday (16/1/2010).
Some doctors and psychiatrists to diagnose the symptoms as the disease schizoprenia and gave antipsychotic drugs. But the drug also not immune to reduce the strangeness of the girl herself. There is also a suspected hit by epilepsy and other diseases. Psychiatrists and doctors became another argument about whether this includes mental illness or neurological disease.
Although MRI was performed tests and electroencephalogram (EEG), but all the results indicate that normal brain activity, there is no unusual findings in the brain. The case of this mysterious illness eventually attract the attention of Dr. Najjar Souhel from NYU's Langone Medical Center. "The first time I saw him, I am very sure he is not only psychiatric disease but also neurological disease," said Dr. Najjar.
"One reason is the dramatic decline of a smart girl and achievement becomes an idiot looking girl," he added. Najjar suspected, there is inflammation in the brain that are not detected by means of magnetic resonance imaging (MRI). Najjar also found several strange antibodies in his body.
"My estimate is that this girl had a rare autoimmune disease, in which the body's immune system actually attacks parts of the body healthy," said Najjar. Prediction and prediction Dr Najjar was indeed true. An antibody test performed, and the results showed that antibodies produced by the body of the girl known to attack the enzyme glutamic acid decarboxylase (GAD).
Enzyme GAD is an enzyme that controls production of a chemical called gamma-aminobutyric acid (GABA), which is a substance that allows the brain to communicate and think. When the body's immune system attacking the GAD enzyme production of GABA become restricted substances. This imbalance will cause psychiatric symptoms and unusual brain's cognitive abilities decline.
Brain biopsy was performed to complete and convincing diagnosis Dr. Najjar. And the results were surprising, to find the girl's brain nerve cells that have died of it comes from inflammation. "That means, antibodies had attacked his brain for years and accumulate until the brain is not strong anymore," said Najjar.
To suppress the inflammation that is not getting worse, Najjar injected corticosteroids on the girl's brain. Immunoglobulin substance was inserted through blood vessels to increase antbodi 'good' antibodies to fight 'evil'. Now, the girls began to show progress. "He talked more and a little delirious. The doctor also said he could continue his schooling," said the mother.
GAD autoimmunity including a mysterious disease that affects fewer people than the entire existing world population. Some children were known to have diabetes antibodies that are directly related to GAD in pancreatic cells. GAD cases experienced by girls.(as cited by Forbes magazine)
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